Alleviation of prochlorperazine-induced primary irritation of skin by cyclodextrin complexation.

• 上釜 兼人

• 入江 徹美

• 砂田 美紀

• 小田切 優樹

• 有松 徳樹

• 野村 茂

抄録

Cyclodextrins (CyDs) protected human erythrocytes from hemolysis induced with prochlorperazine (PCP) in isotonic solution, depending upon the magnitude of the stability constant of PCP-CyD complexes (β- > γ- > α-CyD). The primary irritation produced by PCP on the skin of guinea pigs was found to be reduced by the addition of β- and γ-CyDs, particularly by γ-CyD, while α-CyD enhanced the irritancy of PCP. The most favorable protective effect observed for the γ-CyD complex was mainly ascribable to the weak irritancy of γ-CyD itself, suggesting a great utility of γ-CyD to alleviate the PCP-induced contact dermatitis.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 30 (10), 3860-3862, 1982

  公益社団法人 日本薬学会

キーワード

• alleviation of the contact dermatitis

詳細情報

• CRID: 1390001204164023168
• NII論文ID: 110003634170
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.30.3860
• COI: 1:CAS:528:DyaL3sXislyjtw%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• ISSN: http://id.crossref.org/issn/00092363
• PubMed: 7160028
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/30/10/30_10_3860/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982211572
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可