Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Ostrich Adrenocorticotropic Hormone

• 安村 貢一

  Kyoto College of Pharmacy

• 岡本 憲治

  Kyoto College of Pharmacy

• 島村 真一

  Kyoto College of Pharmacy

• 中村 益久

  Shionogi Research Laboratory, Shionogi Co. Ltd.

• ODAGUCHI KUNIHIRO

  Shionogi Research Laboratory, Shionogi Co. Ltd.

• TANAKA AKIRA

  Shionogi Research Laboratory, Shionogi Co. Ltd.

• YAJIMA HARUAKI

  Faculty of Pharmaceutical Sciences, Kyoto University

抄録

The nonatriaoontapeptide corresponding to the entire amino acid sequence of ostrich adrenocorticotropic hormone (ACTH) was synthesized by successive condensations of four peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-OH, Boc-(5-10)-OH and Z-(1-4)-NHNH_2,with H-(20-39)-OBzl, a synthetic intermediate of ostrich-type corticotropin-like intermediate lobe peptide, followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in TFA. The synthetic peptide exhibited an in vivo steroidogenic potency of 0.8 relative to synthetic human ACTH.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 30 (3), 866-873, 1982-03-25

  公益社団法人日本薬学会

キーワード

• ostrich ACTH
• trifluoromethanesulfonic acid-thioanisole in TFA as a deprotecting system
• m-cresol as a scavenger
• pentachlorophenyl trichloroacetate condensation
• mesitylene-2-sulfonylarginine
• in vivo steroidogenic activity

詳細情報

• CRID: 1570291227416938624
• NII論文ID: 110003634362
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1983180746
• 本文言語コード: en
• データソース種別:
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