Release profiles of 5-fluorouracil and its derivatives from polycarbonate matrices in vitro.

• 川口 健夫

• 中野 眞汎

• 従二 和彦

• 井上 祥平

• 吉田 泰彦

抄録

Release profiles of 5-fluorouracil (5-FU), 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur, tegafur) and 1, 3-bis-(tetrahydro-2-furanyl)-5-fluorouracil (FD-1) from poly-(ethylene carbonate) and poly (propylene carbonate) pellets were examined in vitro. Because of poor compatibility of 5-FU with polycarbonates, 5-FU was quickly released from the pellets. Release of ftorafur from pellets of both polycarbonates was sustained. Release profiles of FD-1 from polycarbonate pellets were complex but extended. Release of ftorafur and FD-1 from pellets of a 9 : 1 mixture of poly (ethylene carbonate) and poly-(propylene carbonate) was less sustained than those from the individual polymers.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 30 (4), 1517-1520, 1982

  公益社団法人 日本薬学会

キーワード

• sustained release

詳細情報

• CRID: 1390001204162499584
• NII論文ID: 110003634472
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.30.1517
• COI: 1:CAS:528:DyaL38Xkt1ymsLw%3D
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 7105267
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/30/4/30_4_1517/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982209508
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可