Alkylation of DNA with a mitomycin derivative, 7-N-(p-hydroxyphenyl)-mitomycin C. Reductive alkylation and preferential binding to adenine.

• 橋本 祐一

• 首藤 紘一

• 岡本 敏彦

抄録

A mitomycin derivative, 7-N-(p-hydroxyphenyl)-mitomycin C (M-83) bound to DNA in vivo and chemically after reductive activation. Enzymatic hydrolysis of the modified DNA obtained chemically gave two modified nucleotides ; 7-N-(p-hydroxyphenyl)-mitosene-deoxyadenylic acid adduct (1) and 7-N-(p-hydroxyphenyl)-mitosene-deoxyguanylic acid adduct (2). One of these modified nucleotides, 1, was identified with the modified nucleotide obtained in vivo. The preferential binding to the adenine moiety in DNA and some of chemical information on the structure of these modified nucleotides are described.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 30 (7), 2644-2646, 1982

  公益社団法人 日本薬学会

キーワード

• modified nucleotide

詳細情報

• CRID: 1390001204161857536
• NII論文ID: 110003634657
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.30.2644
• COI: 1:CAS:528:DyaL38XlslCgtLs%3D
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 7139824
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/30/7/30_7_2644/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982209505
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可