Chemical and toxicological studies on the bracken fern, Pteridium aquilinum var. latiusculum. VI. Isolation of 5-O-caffeoyl shikimic acid as an antithiamine factor

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5-O-Caffeoylshikimic acid (dactylifric acid) was isolated from bracken fern as a major constituent of its acutely toxic fraction, which causes depression of leucocytes and thrombocytes in calves. 5-O-Caffeoylshikimic acid exhibited an antithiamine effect in vitro, but had no hematuric effect in guinea pigs.

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  • Chem Pharm Bull

    Chem Pharm Bull 30 3219-3224, 1982

    公益社団法人日本薬学会

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