Aryl Hydroxylation of 3-Methylacetanilide [4-<SUP>2(3)</SUP>H] by Several Model Systems

• 森 幸雄

• 豊吉 一美

• 馬場 茂雄

抄録

The reactions of tritiated or deuterated 3-methylacetanilide with photolysis of pyridine-N-oxide, m-chloroperbenzoic acid, photolysis of hydrogen peroxide and the Fenton or Udenfriend system has been investigated. The retention of tritium (21%) obtained on the 4-hydroxylation of 3-methylacetanilide-4-³H with pyridine-N-oxide photolysis is corresponding to the tritium retention in the enzymic hydroxylation by rat in vivo and in vitro metabolisms, and the retention value (12%) observed in the reaction with m-chloroperbenzoic acid to the results obtained in the metabolism by rat pretreated with 3, 4-benzpyrene or 3-methylcholanthrene. Isotopic hydrogen in the 3-methyl-4-hydroxyacetanilide produced from 3-methylacetanilide-4-²⁽³⁾H by Fenton or Udenfriend system was also retained. The reactions with these systems under a few conditions are presented.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 24 (6), 1387-1390, 1976

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679154176000
• NII論文ID: 110003635147
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.24.1387
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 1021293
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/24/6/24_6_1387/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1977080732
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可