Pharmacological studies on chinese cinnamon. III. Electroencephalographic studies of cinnamaldehyde in the rabbit.

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Effects of cinnamaldehyde (CA), the main component of Chinese cinnamon which has frequently been prescribed as a remedy in Chinese medicine, on the spontaneous electroencephalograms (EEGs) as well as on the recruiting response and the augmenting response in rabbits were studied. CA converted resting patterns in the EEGs recorded from the frontal cortex, the hippocampus, the amygdala, and the midbrain reticular formation to arousal patterns in the gallamine-paralyzed preparation with the intact brain. In the midpontine pretrigeminal transected preparation, CA also induced an arousal pattern in the electrocorticogram (ECoG). In the low cerveau isole preparation, CA either converted a resting pattern in the ECoG to a sequence of low voltage fast waves or did not elicit such an action depending upon each individual preparation. In the high cerveau isole preparation, CA was not capable of producing any effect on the ECoG. CA, in higher doses, inhibited the recruiting response and the augmenting response. It was concluded that CA produced a centrally originating EEG activation through a direct or indirect excitatory action on the brainstem reticular formation.

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