Cleavage of S-S Bond by Nitric Oxide (NO) in the Presence of Oxygen. A Disproportionation Reaction of Two Disulfides.

• TSUTSUMI Nozomi

• ITOH Takashi

• OHSAWA Akio

抄録

Disulfide bond was cleaved by a catalytic amount of nitric oxide in the presence of oxyge, which was confirmed by experiments employing two symmetrical disulfides. The reaction resulted in the formation of unsym-metrical disulfides in nearly 50% yields. The steric hindrance of alkyl disulfide slowed the reaction rate, and an electron-donating group on the aryl disulfide promoted the reaction. The substituent and S-nitrosothiol effects suggested that the reaction was initialized with an oxidative process by NO⁺.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 48 (10), 1524-1528, 2000

  公益社団法人 日本薬学会

キーワード

• disulfide
• nitric oxide
• disproportionation
• nitrogen oxide
• oxidation
• S-nitrosothiol

詳細情報

• CRID: 1390282679136296192
• NII論文ID: 130003773945
• NII論文ID: 110003635320
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.48.1524
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 5514092
• PubMed: 11045462
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5514092
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/48/10/48_10_1524/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可