CARDIOVASCULAR EFFECT OF "PERITONEAL DIALYSATE-DEPRESSOR-I", A SHORT-ACTIVE HYPOTENSIVE PHOSPHOLIPID IN DOG PERITONEAL DIALYSATE

• YAMADA SADAJI

  Faculty of Pharmaceutical Sciences, University of Tokushima

• TAKAUCHI KENKICHI

  Faculty of Pharmaceutical Sciences, University of Tokushima

• ITAMI TAKAFUMI

  Faculty of Pharmaceutical Sciences, University of Tokushima

• MIYAMOTO TSUMORU

  Faculty of Pharmaceutical Sciences, University of Tokushima

• TSUKATANI HIROAKI

  Faculty of Pharmaceutical Sciences, University of Tokushima

抄録

Cardiovascular action of" peritoneal dialysate-depressor-I" (PD. D-I), a short-acting hypotensive phospholipid occurring in dog peritoneal dialysate, was investigated. With an intravenous injection of PD. D-I into an anaesthetized rat, a sharp fall of arterial blood pressure was observed and the effects were dose dependent. The maximum hypotensive effect was about 60 mmHg and the minimum effective dose was approximately 35 μg/kg. Neither tachyphylaxis nor sensitization was observed. Even in conscious rats PD. D-I elicited hypotensive responses, though the effect was much weaker than that produced in anaesthetized rats. In spinal rats the hypotensive effects were also observed. In the tests on rats reserpinized or pretreated with antimuscarinic, antihistaminic, β-adrenergic-blocking and ganglionic-blocking agents, the depressor effect of PD. D-I was not affected. PD. D-I elicited also hypotensive responses in anaesthetized cats, rabbits and guinea pigs in the same degree as those in anaesthetized rats. The relaxation of the peripheral blood vessels was observed in the test on perfused rabbit ear. The depressor factor showed no smooth muscle stimulating activity in isolated guinea pig ileum preparations. Judging from these findings, the hypotensive effect of PD. D-I is not ascribable to the central, sympathetic or parasympathetic nervous system but possibly to direct action on the peripheral vascular system.

収録刊行物

• Journal of pharmacobio-dynamics

  Journal of pharmacobio-dynamics 3 (8), 367-373, 1980-08

  公益社団法人日本薬学会

キーワード

• "peritoneal dialysate-depressor-I"(PD. D-I)
• short-active hypotensive phospholipid
• vasodepressor activity in various animal species
• hypotension in conscious rats
• lyso-phosphatide
• direct action on peripheral vascular system

詳細情報

• CRID: 1572261552254541056
• NII論文ID: 110003635945
• NII書誌ID: AA00704585
• ISSN: 0386846X
• 本文言語コード: en
• データソース種別:
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