A DUAL ACTION OF MUSCARINIC PARTIAL AGONISTS ON PUPIL SIZE OF RABBIT

  • TERASHIMA ETSUKO
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
  • TAKAYANAGI ISSEI
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
  • OHASHI MITSUO
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences

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Pentanoylcholine iodide and n-hexyltrimethylammonium bromide were muscarinic partial agonists in a sphincter pupillae muscle of rabbit as well as intestinal smooth muscles. Both partial agonists behaved as mydriatics in a constricted pupil and as miotics in a dilated pupil.

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