Antitumor activity of acidic mannan fraction form baker's yeast

• HASHIMOTO K.

  Department of Microbiology

• OKAWA YOSHIO

  Department of Microbiology

• SUZUKI KO

  Department of Microbiology

• OKURA YASUSHI

  Department of Microbiology

• SUZUKI SHIGEO

  Second Department of Hygienic Chemistry

• SUZUKI MASUKO

  Tohoku College of Pharmacy

抄録

The acidic fraction of bakers' yeast mannan containing mannose (93.6%), nitrogen (1.0%), and phosphorus (0.6%), designated as WAM025,showed a marked antitumor activity against the ascites forms of Ehrlich, sarcoma 180 and Meth A tumors in vivo. Namely, a 100% survival of mice transplanted with Ehrlich or sarcoma 180 ascites tumor, 1×10^5 cells/ddY strain mouse, was obtained by the intraperitoneal administration of WAM025,150 mg/kg/d for 10 d. This effect evoked by WAM025 seems to be attributed to the activation of peritoneal adherent cells in mice, because a significant elevation of lysosomal enzyme level and active oxygen generation was observed on the peritoneal adherent cells obtained from the mannan-administered mice.

収録刊行物

• J. Pharm. Dyn.

  J. Pharm. Dyn. 6 668-676, 1983

  公益社団法人日本薬学会

キーワード

• acidic mannan
• ascites tumor
• antitumor activity
• lysosomal enzyme
• active oxygen

詳細情報

• CRID: 1573387452160923136
• NII論文ID: 110003636662
• NII書誌ID: AA00704585
• ISSN: 0386846X
• Web Site: https://search.jamas.or.jp/link/ui/1984071972
• 本文言語コード: en
• データソース種別:
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