Cytotoxicity and Antitumor Activities of Fungal Bis (naphtho-γ-pyrone) Derivatives
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- KOYAMA K.
- Meiji College of Pharmacy Cancer Chemotherapy Center
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- OMINATO Kimie
- Meiji College of Pharmacy Cancer Chemotherapy Center
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- NATORI Shinsaku
- Meiji College of Pharmacy Cancer Chemotherapy Center
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- TASHIRO Tazuko
- Meiji College of Pharmacy Cancer Chemotherapy Center
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- TSURUO Takashi
- Meiji College of Pharmacy Cancer Chemotherapy Center
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抄録
Cytotoxicities of twenty-seven fungal naphtho-γ-pyrone derivatives to KB cells were examined. Chaetochromins A-D (1-4) and ustilaginoidins D (10) and E (11) exhibited strong effects and the structure-activity relationships are discussed. The antitumor effects in vivo of some of these compounds were examined but, due to their toxicity and to their marginal activity, development as antitumor agents was abandoned. Deoxyribonucleic acid, ribonucleic acid and protein synthesis in KB cells were equally inhibited by chaetochromin A (1), cephalochromin (5), and ustilaginoidin A (7) in parallel with the cytotoxicity of the drugs. Thus it was suggested that other still unknown mechanism (s) might induce cytotoxic leison, resulting in the inhibition of the macromolecule syntheses.
収録刊行物
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- J. Pharmacobio-Dyn.
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J. Pharmacobio-Dyn. 11 630-635, 1988
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1571980077277885184
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- NII論文ID
- 110003636914
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- NII書誌ID
- AA00704585
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- ISSN
- 0386846X
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles