Effect of Lithium Carbonate Administration Singly or in Combination with Some Psychotropic Drugs on the Radioiodide Uptake by Mouse Thyroid

  • TAKASUGI Masumitsu
    Department of Pharmacy, University Hospital, School of Medicine Faculty of Pharmaceutical Sciences, The University of Tokushima Faculty of Pharmaceutical Sciences, Josai University
  • TERAOKA Kazuhiko
    Department of Pharmacy, University Hospital, School of Medicine Faculty of Pharmaceutical Sciences, The University of Tokushima Faculty of Pharmaceutical Sciences, Josai University
  • MINAKUCHI Kazuo
    Department of Pharmacy, University Hospital, School of Medicine Faculty of Pharmaceutical Sciences, The University of Tokushima Faculty of Pharmaceutical Sciences, Josai University
  • AKAMATSU Seiji
    Department of Pharmacy, University Hospital, School of Medicine Faculty of Pharmaceutical Sciences, The University of Tokushima Faculty of Pharmaceutical Sciences, Josai University
  • NISHIDA Mikio
    Department of Pharmacy, University Hospital, School of Medicine Faculty of Pharmaceutical Sciences, The University of Tokushima Faculty of Pharmaceutical Sciences, Josai University
  • KAMATA Naoyuki
    Department of Pharmacy, University Hospital, School of Medicine Faculty of Pharmaceutical Sciences, The University of Tokushima Faculty of Pharmaceutical Sciences, Josai University
  • KUWAE Toyoyasu
    Department of Pharmacy, University Hospital, School of Medicine Faculty of Pharmaceutical Sciences, The University of Tokushima Faculty of Pharmaceutical Sciences, Josai University
  • KURATA Munetsugu
    Department of Pharmacy, University Hospital, School of Medicine Faculty of Pharmaceutical Sciences, The University of Tokushima Faculty of Pharmaceutical Sciences, Josai University
  • KAWADA Jun
    Department of Pharmacy, University Hospital, School of Medicine Faculty of Pharmaceutical Sciences, The University of Tokushima Faculty of Pharmaceutical Sciences, Josai University

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The present study dealt with two objects ; the first object was to examine whether or not lithium uptake in thyroid is modified by the thyroid state and how the intrathyroidal Li affects iodide uptake by the thyroid. Male and female mice were given lithium carbonate (Li) with propylthiouracil (PTU) or thyroxine (T_4). Li was measured by a flameless atomic absorption spectrometry. The total Li content in thyroid was unaffected with PTU or T_4,however, Li concentration per unit mass was reduced by PTU but unaffected by T_4. The thyroid : serum ratio (T/S) of ^<125>I resulted that the T/S became higher when Li concentration per unit mass was lower and vice versa, suggesting that Li uptake is controlled by thyroid states and Li in the gland interferes with the iodide uptake. Serum triiodothyronine (T_3) and T_4 by radioimmunoassay showed that PTU alone and in combination with Li lowered serum T_4,while a high level of T_4 by its supplement was suppressed by co-administration of Li. T_3 level was lowered by Li alone, but not severely affected by other drugs. The results suggest that Li enhances T_4 clearance without T_4-T_3 conversion. The second object was to examine the effect of combined psychotropic drugs on thyroid function. Carbamazepine (CBZ), haloperidol (HLP) and imipramine (IPA) were given singly or in combination with Li to examine their effects on the T/S of ^<125>I. Only CBZ reduced the T/S but CBZ plus Li had no summative effect. Neither HLP nor IPA affected the T/S, singly or in combination with Li, suggesting that HLP or IPA does not interfere with an iodide pumping machinery. No distinct sex difference was observed in drug effects.

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