Methylprednisolone reduces the nephrotoxicity caused by cisplatin.

• UOZUMI Jiro

• KOIKAWA Yasuhiro

• UEDA Toyofumi

抄録

Male Sprague-Dawley rats were given either 6.5 or 8.5 mg/kg of iv cisplatin combined with three injections of sc methylprednisolone in doses of either 50, 100 or 250 mg/kg at -4, 0 and 4 h after the cisplatin injection. Blood urea nitrogen and serum creatinine levels were determined on day 5 following the cisplatin injection. The protective effects of methylprednisolone on cisplatininduced nephrotoxicity were clearly demonstrated. Our preliminary results suggest that a much higher dose of cisplatin could be injected in cancer chemotherapy, if it was combined with methylprednisolone.

収録刊行物

• Journal of Pharmacobio-Dynamics

  Journal of Pharmacobio-Dynamics 15 (12), 693-697, 1992

  公益社団法人 日本薬学会

キーワード

• nephrotoxicity

詳細情報

• CRID: 1390001204621804672
• NII論文ID: 110003637487
• NII書誌ID: AA00704585
• DOI: 10.1248/bpb1978.15.693
• COI: 1:CAS:528:DyaK3sXitVGnur8%3D
• ISSN: 18811353
• ISSN: 0386846X
• ISSN: http://id.crossref.org/issn/0386846X
• PubMed: 1296980
• Web Site: http://www.jstage.jst.go.jp/article/bpb1978/15/12/15_12_693/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1994106870
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可