Different effect of 4-(4'-chlorobenzyloxy) benzoic acid (MII) on lipid synthesis and cell growth in human and mouse skin fibroblasts
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- IRIKURA T
- Kyorin Central Research Laboratories
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- TAKAGI KOUICHI
- Kyorin Central Research Laboratories
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- OKADA KODO
- Kyorin Central Research Laboratories
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- OKAZAKI TAKASHI
- Kyorin Central Research Laboratories
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- YAGASAKI KAZUMI
- Kyorin Central Research Laboratories
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The effect of 4-(4'-chlorobenzyloxy)benzoic acid (MII), a metabolite of a new hypolipidemic agent 4-(4'-chlorobenzyloxy)benzyl nicotinate (KCD-232), on lipid synthesis and cell growth was studied in human skin fibroblasts (HSF), mouse skin fibroblasts (MSF) and other rodent-derived cell. MII inhibited sterol synthesis in both HSF and MSF in a dose dependent manner. The drug also suppressed fatty acid synthesis, weakly in HSF and markedly in MSF. The growth of MSF was inhibited by MII in a dose dependent manner, whereas that of HSF was not inhibited at all by MII up to 1 mM. The MII-mediated inhibition of MSF growth was not prevented by the addition to the medium of intermediates of the cholesterol synthetic pathway, i.e., mevalonate, squalene or lanosterol. Furthermore, the growth of several cell lines derived from rodents (L, CHL and AH109A cells) was suppressed by MII. These results suggested a possibility that the different effects of MII on the growth of HSF and MSF might be due partly to differences in the effect of MII on fatty acid synthesis between human and rodent cells.
収録刊行物
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- J Pharmacobiodyn
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J Pharmacobiodyn 8 1018-1023, 1985
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1571417127324492416
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- NII論文ID
- 110003637878
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- NII書誌ID
- AA00704585
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- ISSN
- 0386846X
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles