ENHANCED RECTAL ABSORPTION OF β-LACTAM ANTIBIOTICS IN RAT BY MONODESMOSIDES ISOLATED FROM PERICARPS OF SAPINDUS MUKUROSSI (ENMEI-HI)
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- YATA NOBORU
- Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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- SUGIHARA NARUMI
- Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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- YAMAJO RYOKO
- Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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- MURAKAMI TERUO
- Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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- HIGASHI YUTAKA
- Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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- KIMATA HIROKO
- Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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- NAKAYAMA KEISO
- Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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- KUZUKI TATSUO
- Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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- TANAKA OSAMU
- Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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抄録
Monodesmosides, saponin A, B and C, isolated from pericarps of Sapindus mukurossi(Enmei-hi) were shown to promote the rectal absorption of β-lactam antibiotics in rat, using an in situ loop method and an in vivo method. In the in situ loop method, monodesmosides were solubilized with a mixture of bisdesmosides, mukurozi-saponin X, Y_1 and Y_2,each of which was isolated from pericarps of Sapindus mukurossi. The promoting functions of the three monodesmosides for the rectal absorption of antibiotics were comparable and also suppressed by Ca^<2+> ion coexisting in the administered solution. Unlike the case of N-acylcollagenpeptides, which were also previously reported as absorption promoters, no influence of osmolarity of the administered solution on the absorption promoting action was observed. Absorption of β-lactam antibiotics from suppositories was enhanced with the aid of either of monodesmosides without solubilizing agent.
収録刊行物
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- Journal of pharmacobio-dynamics
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Journal of pharmacobio-dynamics 8 (12), 1041-1047, 1985-12
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詳細情報
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- CRID
- 1571135652347769088
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- NII論文ID
- 110003637881
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- NII書誌ID
- AA00704585
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- ISSN
- 0386846X
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles