Prevention of the Neurotoxicity of the Amyloid .BETA. Protein by Genipin.

• YAMAZAKI Matsumi

  Department of Biodynamics, Faculty of Pharamaceutical Sciences, Hokuriku University

• SAKURA Naoki

  Department of Bio-Organic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• CHIBA Kenzo

  Department of Biodynamics, Faculty of Pharamaceutical Sciences, Hokuriku University

• MOHRI Tetsuro

  Department of Biodynamics, Faculty of Pharamaceutical Sciences, Hokuriku University

抄録

Genipin, which was shown in our previous investigation to have prominent neuritogenic activity in paraneurons such as PC12h cells, was studied to determine whether it could prevent the toxicity of Alzheimer’s amyloid β protein (Aβ) in cultured hippocampal neurons. Increased release of lactate dehydrogenase from hippocampal neurons after 2 d of Aβ25-35 administration was prevented dose dependently by the addition of genipin 20—40 μM. Morphological observations and trypan blue staining of cells confirmed the protection of hippocampal neurons from Aβ toxicity by genipin. Geniposide had less effect in preventing Aβ toxicity.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 24 (12), 1454-1455, 2001

  公益社団法人 日本薬学会

キーワード

• amyloid β protein
• hippocampal neuron
• genipin
• neurotoxicity
• neuroprotection

詳細情報

• CRID: 1390282679603956864
• NII論文ID: 110003638442
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.24.1454
• COI: 1:CAS:528:DC%2BD3MXosl2rs7k%3D
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 11767124
• Web Site: http://www.jstage.jst.go.jp/article/bpb/24/12/24_12_1454/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002164610
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可