Effects of Dermatan and Dextran Sulfates on Arginine Amidase Activity Released from Isolated Rabbit Arteries.
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- TAKEUCHI Koichi
- Department of Clinical Pharmacology, Meiji Pharmaceutical University
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- MIYAZAKI Kyousuke
- Seikagaku Kogyo Co.
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- ISHI-NOZAWA Reiko
- Department of Clinical Pharmacology, Meiji Pharmaceutical University
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- CHIBA Ryoko
- Laboratory of Analytical Chemistry of Medicines, Showa College of Pharmaceutical Sciences
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- SHIMOKAWA Ken-ichi
- Department of Functional Bioanalysis, Meiji Pharmaceutical University
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- KATAYAMA Masatoki
- Department of Functional Bioanalysis, Meiji Pharmaceutical University
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- MATSUDA Yoshifumi
- Department of Functional Bioanalysis, Meiji Pharmaceutical University
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Abstract
We examined the levels of arginine amidase secreted from isolated rabbit arteries treated with dermatan and dextran sulfates, and the relation between the secretion of arginine amidase activity and the concentration of dermatan sulfate added to these arteries. The results showed that while dextran sulfate tended to accelerate the release of arginine amidase activity from the isolated rabbit ear artery, the induction was not significant. There was a significant increase in the level of arginine amidase released from the lower portion of isolated rabbit aorta (p<0.05), but no significant change in the upper portion of the aorta. In contrast, the addition of dermatan sulfate significantly increased the level of arginine amidase activity released from the isolated rabbit ear artery and the upper and lower portions of the aorta (p<0.05). Linear dose-response relationships were observed between the level of arginine amidase activity released from the isolated rabbit ear artery and aorta and the concentration of dermatan sulfate added.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 24 (5), 465-469, 2001
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679603318528
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- NII Article ID
- 110003638493
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- NII Book ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3MXjt1alsb0%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 5763854
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- PubMed
- 11379761
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed