Effect of Antiallergic Drugs on Interleukin 5-Induced Eosinophil Infiltration of Rat Airways.

• Takizawa Toshiaki

  Department of Pharmacology, Gifu Pharmaceutical University

• Kawada Naoki

  Department of Pharmacology, Gifu Pharmaceutical University

• Tanaka Hiroyuki

  Department of Pharmacology, Gifu Pharmaceutical University

• Nagai Hiroichi

  Department of Pharmacology, Gifu Pharmaceutical University

抄録

Interleukin (IL)-5 is thought to play important roles in asthma and to be a potential therapeutic target. An intratracheal injection of murine recombinant IL-5 (3—30 μg/animal) induced a dose-dependent increase in the number of eosinophils in the bronchoalveolar lavage fluid of Brown Norway (BN) rats 24 h after administration. Bovine serum albumin (30 μg/animal), used as reference material, did not cause any change. The reaction was not observed in F344 rats. The increase in the number of eosinophils did not accompany bronchial hyperreactivity in BN or F344 rats. Prednisolone (3—10 mg/kg, i.p.) and emedastine (30 mg/kg, p.o.) reduced the increased number of eosinophils induced by the IL-5 challenge. These results suggest that IL-5 is a potent inducer of eosinophils in the airway of BN rats. Prednisolone and emedastine are effective against IL-5-induced eosinophilia.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 25 (3), 318-322, 2002

  公益社団法人 日本薬学会

キーワード

• interleukin 5 (IL-5)
• eosinophil
• Brown Norway rat
• emedastine

詳細情報

• CRID: 1390282679604321664
• NII論文ID: 110003638694
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.25.318
• COI: 1:CAS:528:DC%2BD38XkslWltrY%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 6263139
• PubMed: 11913525
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6263139
• Web Site: http://www.jstage.jst.go.jp/article/bpb/25/3/25_3_318/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002165675
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可