Identification of Licocoumarone as an Apoptosis-Inducing Component in Licorice.

• Watanabe Makoto

  School of Food and Nutritional Sciences, University of Shizuoka

• Hayakawa Sumio

  School of Food and Nutritional Sciences, University of Shizuoka

• Isemura Mamoru

  School of Food and Nutritional Sciences, University of Shizuoka

• Kumazawa Shigenori

  School of Food and Nutritional Sciences, University of Shizuoka

• Nakayama Tsutomu

  School of Food and Nutritional Sciences, University of Shizuoka

• Mori Chihiro

  Tokiwa Phytochemical Co., Ltd.

• Kawakami Toshioki

  Sanpo Co., Ltd.

抄録

The 70% methanol soluble fraction from a licorice acetone extract was found to inhibit cell proliferation in human monoblastic leukemia U937 cells by inducing apoptosis. Separation by the methods including preparative HPLC provided us with an active compound, which was identified as licocoumarone. Several lines of evidence indicated that licocoumarone induced apoptosis in U937 cells. Thus, licocoumarone is suggested to be potentially useful as a natural anti-cancer agent.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 25 (10), 1388-1390, 2002

  公益社団法人 日本薬学会

キーワード

• licorice
• apoptosis
• licocoumarone
• <i>Glycyrrhiza glabra</i>
• U937 cell

詳細情報

• CRID: 1390282679603009536
• NII論文ID: 110003638919
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.25.1388
• COI: 1:CAS:528:DC%2BD38XosFymtr8%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 6313767
• PubMed: 12392103
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6313767
• Web Site: http://www.jstage.jst.go.jp/article/bpb/25/10/25_10_1388/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003115366
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可