Decalcification of Calcium Polycarbophil in Rats.

• YAMADA Takehisa

• SAITO Takaharu

• TAKAHARA Eiji

• NAGATA Osamu

• TAMAI Ikumi

• TSUJI Akira

書誌事項

タイトル別名

• Decalcification of Calcium Polycarbophi

抄録

The in vivo decalcification of calcium polycarbophil was examined. The decalcification ratio of [⁴³Ca]calcium polycarbophil in the stomach after oral dosing to rats was more than 70% at each designated time and quite closely followed the in vitro decalcification curve, indicating that hte greater part of the calcium ion is released from calcium polycarbophil under normal gastric acidic conditions. The residual radioactivity in rat gastrointestine was nearly equal to that after oral administration of either [⁴⁵Ca]calcium chloride or [⁴⁵Ca]calcium chloride+polycarbophil. The serum level of radioactivity was nearly equal to that after oral dosing of [⁴⁵Ca]calcium lactate. These results indicate that the greater part of orally administered calcium polycarbophil released calcium ions to produce polycarbophil in vivo.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 20 (3), 275-277, 1997

  公益社団法人 日本薬学会

キーワード

• calcium polycarbophil
• polycarbophil
• decalcification
• calcium absorption
• rat

詳細情報

• CRID: 1390282679598065024
• NII論文ID: 110003639038
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.20.275
• COI: 1:CAS:528:DyaK2sXitVKhu70%3D
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• NDL書誌ID: 4163692
• PubMed: 9084886
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4163692
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/20/3/20_3_275/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997202501
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可