The Enhancing Mechanism of Capric Acid (C10) from a Suppository on Rectal Drug Absorption through a Paracellular Pathway.

• TAKAHASHI Hideyuki

• SHIBASAKI Tamayo

• TAKESHITA Kenichi

• KAIHO Fusao

• HAYASHI Masahiro

書誌事項

タイトル別名

• Enhancing Mechanism of Capric Acid C10

抄録

Capric acid (C10) enhanced the absorption of cefoxitin sodium in a concentration-dependent manner following the rectal administration as a suppository in rats. The optimal concentration of C10 was 13%. C10 administered as a suppository also reduced rectal membrane resistance (R_m), showing that the above enhancing effect was induced by widening the paracellular pathway. Both the enhancing effect on the absorption and the reducing effect on R_m were inhibited by W7, an inhibitor of myosin light chain kinase. These results supported that, as shown in the in vitro Caco-2 cell system, the C10 effect on the paracellular pathway is due to activating the contraction of Ca²⁺-calmodulin-dependent actin filament.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 20 (4), 446-448, 1997

  公益社団法人 日本薬学会

キーワード

• capric acid
• absorption enhancer
• rectal absorption
• suppository
• paracellular pathway
• actin filament

詳細情報

• CRID: 1390001204621636736
• NII論文ID: 110003639075
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.20.446
• COI: 1:CAS:528:DyaK2sXislahu7o%3D
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• NDL書誌ID: 4188188
• PubMed: 9145228
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4188188
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/20/4/20_4_446/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可