Studies on Alismatis Rhizoma.1.Anti-allergic Effects of Methanol Extract and Six Terpene Components from Alismatis Rhizoma(Dried Rhizome of Alisma orientale)
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- Studies on Alismatis Rhizoma. I. Anti-allergic Effects of Methanol Extract and Six Terpene Components from Alismatis Rhizoma (Dried Rhizome of Alisma orientale).
- Studies on Alismatis Rhizoma.1.Anti-all
- Studies on Alisma rhizome. I. Anti-allergic effects of methanol extract and six terpene components from Alisma rhizome (dried rhizome of Alisma orientale)
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Methanol and aqueous extracts (TMe-ext and TAq-ext) from dried rhizomes of Alisma orientale have been screened for activity in experimental models of type I-IV allergies. In the type III allergic model, TMe-ext at oral doses of 50, 200 mg/kg showed an inhibitory effect on the direct passive Arthus reaction (DPAR) in rats, while TAq-ext did not. Four triterpenes (alisol A, alisol B, alisol A monoacetate and alisol B monoacetate) and two sesquiterpenes (alismol and alismoxide) isolated from TMe-ext also exhibited this inhibitory effect. In a type I allergic model, TMe-ext inhibited 48-h homologoes passive cutaneous anaphylaxis (PCS) in rats. In a typ II allergic model, it was found that TMe-ext inhibits reversed cutaneous anaphylaxis (RCA) in rats. Furthermore, in a type IV allergic model, TMe-ext has an inhibitory effect on the induction phase in picryl chloride-induced contact dermatitis (PC-CD) in mice. These results indicate that Alismatis Rhizoma not only inhibits antibody-mediated allergic reactions but also influences cell reactions and should be recognized as a material for the treatment of allergic reactions, and the anti-type III allergic components are partially attributable to the terpenes mentioned above.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 20 (5), 511-516, 1997
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679598961024
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- NII論文ID
- 110003639090
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK2sXjsV2lsLc%3D
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- ISSN
- 13475215
- 09186158
- http://id.crossref.org/issn/09186158
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- NDL書誌ID
- 4220098
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- PubMed
- 9178931
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可