Antiviral Substance from Silkworm Faeces: Purification and Its Chemical Characterization.

• HIRAKI Akihiro

• YUKAWA Masayuki

• KIM Jeman

• UEDA Shigeharu

書誌事項

タイトル別名

• Antiviral Substance from Silkworm Faece

抄録

In a previous paper, we reported that an extract of silkworm faeces has a marked antiviral activity on enveloped viruses, but not on a non-enveloped virus, and we showed that it inhibits the synthesis of a viral specific gene of HVJ (Sendai virus) without affecting the viral adsorption and entry into the host cell. In this paper, we accomplished the purification of an antiviral active substance by extraction of a hydrophobic substance and thin layer chromatography. The active substance was found to be a chlorophyll-like substance with a molecular mass of about 530. This substance shows clear antiviral activity against HVJ, HSV (herpes simplex virus type-1), and HIV (humanimmunodeficiency virus type-1). Its antiviral activity was dependent on light irradiation and temperature. Furthermore, it also possesses a strong hemolytic activity under light.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 20 (5), 547-555, 1997

  公益社団法人 日本薬学会

キーワード

• silkworm faeces
• chlorophyll-like substance
• enveloped virus
• HVJ (Sendai virus)
• light irradiation

詳細情報

• CRID: 1390001204622272512
• NII論文ID: 110003639096
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.20.547
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 4220107
• PubMed: 9178937
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4220107
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/20/5/20_5_547/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997191110
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可