Involvement of Calciseptine-Sensitive Calcium Channels in the Evoked Acetylcholine Release from Electric Organ Synaptosomes.

• TOKUMARU Hiroshi

• SATOH Yasushi

• HIRASHIMA Naohide

• SHOJAKU Suzuyo

• YAMAMOTO Haruhiko

• KIRINO Yutaka

書誌事項

タイトル別名

• Involvement of Calciseptine-Sensitive C

抄録

The high K⁺ -evoked release of acetylcholine (ACh) from electric organ synaptosomes isolated from the Japanese marine ray, Narke japonica, was strongly inhibited by dihydropyridines at micromolar concentrations. However, this inhibition seems to be a non-specific effect sine the agonist (-)-Bay K 8644 also had inhibitory effects. Calciseptine, a peptide toxin specific for L-type Ca channels, inhibited to a lesser extent the evoked acetylcholine release : the maximum inhibition was about 20%. This finding is in accord with our data (Tokumaru et al., J. Neurochem., 65, 831 (1995)) regarding inhibition by a monoclonal antibody against the α₂δ-subunit of the L-type Ca channel and provides evidence for the involvement of an L-type-like Ca channel in ACh release in addition to ω-conotoxin GVIA-sensitive N-type and ω-agatoxin IVA-sensitive P-type Ca channels.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 20 (6), 641-645, 1997

  公益社団法人 日本薬学会

キーワード

• presynaptic nerve terminal
• acetylcholine release
• calciseptine
• L-type-like Ca channel
• electric organ synaptosome

詳細情報

• CRID: 1390282679599277184
• NII論文ID: 110003639116
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.20.641
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 4240339
• PubMed: 9212982
• Web Site: http://id.ndl.go.jp/bib/4240339
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4240339
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/20/6/20_6_641/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可