Uptake of Methylchlorpromazine by Brush-Border Membrane Vesicles from Rat Small Intestine.

• SAITOH Hiroshi

• MIYAZAKI Katsumi

書誌事項

タイトル別名

• Uptake of Methylchlorpromazine by Brush

抄録

The uptake of methylchlorpromazine (MCP), a quaternary derivative of chlorpromazine, was investigated using brush-border membrane vesicles islated from rat small intestine. MCP was taken up rapidly by the vesicles, a major part of the uptake being due to binding to the membrane. Saturable MCP binding to the brush-border membrane was inhibited strongly by chlorpromazine, moderately by propantheline and imipramine, and slightly but significantly by methylbenactyzine and mepenzolate. However, choline and tetramethylammonium failed to exhibit any such inhibitory effect. The movement of MCP into the intravesicular space was driven by an inside-negative transmembrane electrical potential difference (TEPD) induced by NaSCN or valinomycin. There was no effect of TEPD on MCP binding to the brush-border membrane. The data suggested that both rapid binding to the brush-border membrane and inside-negative TEPD, which is present physiologically across the membrane, play a significant role in the absorptive movements of MCP across intestinal epithelium.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 20 (6), 662-666, 1997

  公益社団法人 日本薬学会

キーワード

• methylchlorpromazine uptake
• membrane binding
• membrane potential
• brush-border membrane
• rat small intestine

詳細情報

• CRID: 1390282679599295616
• NII論文ID: 110003639120
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.20.662
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 4240343
• PubMed: 9212986
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4240343
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/20/6/20_6_662/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997249511
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可