The effects of Hange-shashin-to on the content of prostaglandin E2 and water absorption in large intestine of rats
書誌事項
- タイトル別名
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- The Effects of Hange-shashin-to on the Content of Prostaglandin E2 and Water Absorption in the Large Intestine of Rats.
- Effects of Hange-shashin-to on the Cont
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The effects of Hange-shashin-to (TJ-14) were examined regarding the amount of prostaglandin E2 (PGE2) and the water absorbind capacity in the large intestine of rats. Repeated oral administration of TJ-14 at doses of 125 to 1000 mg/kg revealed a significant decrease in PGE2 content in the colonic mucosa and also the promotion of colonic water absorption in a dose dependent manner. However, there was no remarkable influence on the concentrations of aldosterone and electrolytes in the serum, even at 1000 mg/kg. From these results, it was considered that some of the anti-diarrheal effects of TJ-14 might be based on a repression of the increase in the amount of PGE2 as well as promotion of the water absorbing capacity of the large intestine. Moreover, it was also suggested that it is possible, by the application of TJ-14, to prevent the loss of water content caused by diarrhea.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 20 (9), 954-957, 1997
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679599721216
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- NII論文ID
- 110003639183
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK2sXmtl2qsrs%3D
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- ISSN
- 13475215
- 09186158
- http://id.crossref.org/issn/09186158
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- NDL書誌ID
- 4307710
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- PubMed
- 9331975
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可