Metabolism of 6"-O-Xylosyltectoridin and Tectoridin by Human Intestinal Bacteria and Their Hypoglycemic and in Vitro Cytotoxic Activities

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Abstract

6"-O-Xylosyltectoridin and tectoridin isolated from the flowers of Pueraria thunbergiana (Leguminosae), are metabolized to tectorigenin by human intestinal bacteria. Although tectoridin is metabolized to tectorigenin by most intestinal bacteria, 6"-O-xylosyltectoridin is metabolized to tectorigenin via tectoridin by only a few intestinal bacteria, such as Bifidobacterium breve K-110 and Eubacterium A-44. The metabolite, tectorigenin, had more potent hypoglycemic activity as well as in vitro cytotoxic activity against tumor cell lines than 6"-O-xylosyltectoridin and tectoridin. These results suggest that 6"-O-xylosyltectoridin and tectoridin. These results suggest that 6"-O-xylosyltectoridin and tectoridin are prodrugs which can be transformed to the active agents by human intestinal bacteria.

Journal

Biological & pharmaceutical bulletin   [List of Volumes]

Biological & pharmaceutical bulletin 22(12), 1314-1318, 1999-12-15  [Table of Contents]

The Pharmaceutical Society of Japan

References:  12

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Codes

  • NII Article ID (NAID) :
    110003639602
  • NII NACSIS-CAT ID (NCID) :
    AA10885497
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    09186158
  • NDL Article ID :
    4938493
  • NDL Source Classification :
    ZS51(科学技術--薬学)
  • NDL Call No. :
    Z53-V41
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE