Metabolism of 6″-O-Xylosyltectoridin and Tectoridin by Human Intestinal Bacteria and Their Hypoglycemic and in Vitro Cytotoxic Activities

• BAE Eun-Ah

• HAN Myung Joo

• LEE Kyung-Tae

• CHOI Jong-Won

• PARK Hee-Juhn

• KIM Dong-Hyun

書誌事項

タイトル別名

• Metabolism of 6''-O-Xylosyltectoridin and Tectoridin by Human Intestinal Bacteria and Their Hypoglycemic and in Vitro Cytotoxic Activities.

抄録

6"-O-Xylosyltectoridin and tectoridin isolated from the flowers of Pueraria thunbergiana (Leguminosae), are metabolized to tectorigenin by human intestinal bacteria. Although tectoridin is metabolized to tectorigenin by most intestinal bacteria, 6"-O-xylosyltectoridin is metabolized to tectorigenin via tectoridin by only a few intestinal bacteria, such as Bifidobacterium breve K-110 and Eubacterium A-44. The metabolite, tectorigenin, had more potent hypoglycemic activity as well as in vitro cytotoxic activity against tumor cell lines than 6"-O-xylosyltectoridin and tectoridin. These results suggest that 6"-O-xylosyltectoridin and tectoridin. These results suggest that 6"-O-xylosyltectoridin and tectoridin are prodrugs which can be transformed to the active agents by human intestinal bacteria.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 22 (12), 1314-1318, 1999

  公益社団法人 日本薬学会

キーワード

• intestinal bacteria
• 6"-O-xylosyltectoridin
• tectoridin
• tectorigenin
• hypoglycemic activity
• cytotoxicity

詳細情報

• CRID: 1390282679601688192
• NII論文ID: 110003639602
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.22.1314
• COI: 1:CAS:528:DC%2BD3cXitlWi
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• NDL書誌ID: 4938493
• PubMed: 10746163
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4938493
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/22/12/22_12_1314/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000094786
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可