Transport and Recognition of Aminopeptidase-Resistant Cellobiose-Coupled Tyrosylglycylglycine by Intestinal Na+/Glucose Cotransporter (SGLT1): Recognition of Sugar Conjugates by SGLT1 Is Much Less Restricted than Transport.

• MIZUMA Takashi

• SAKAI Norio

• HAGI Katsura

• AWAZU Shoji

抄録

Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine (CcpTGG) by intestinal Na⁺/glucose cotransporter (SGLT1) was examined in rat small intestine. Inhibitory effect of phloridzin (SGLT1 inhibitor) on the CcpTGG transport was extremely low. Concentration dependence of the CcpTGG transport was observed, but the primary component of transport was pasisve diffusion However, CcpTGG significantly inhibited SGLT1-mediated transport, indicating its recognition by SGLT1. Other glucose-conjugates also inhibited SGLT1-mediated transport. These results indicate that recognition of sugar conjugates by SGLT1 is much less restricted than transport, and that it should be relatively easier to design SGLT1 inhibitors than SGLT1-transportable sugar conjugates.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 22 (8), 876-879, 1999

  公益社団法人 日本薬学会

キーワード

• sodium ion/glucose contransporter
• SGLT1
• sugar conjugate
• transport
• recognition

詳細情報

• CRID: 1390282679603289472
• NII論文ID: 110003639779
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.22.876
• COI: 1:CAS:528:DyaK1MXlsVOnsrs%3D
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• NDL書誌ID: 4834790
• PubMed: 10480331
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4834790
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/22/8/22_8_876/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000025506
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可