Acute effects of Crocus sativus L. on passive avoidance performance in mice

• 張 永祥

• 正山 征洋

• 杉浦 実

• 齋藤 洋

書誌事項

タイトル別名

• Effects of Crocus sativus L. on the Ethanol-Induced Impairment of Passive Avoidance Performances in Mice.

抄録

The acute effects of an alcohol extract of Crocus sativus L. (CS-extract) were studied on learning and memory in step through (ST) and step down (SD) tests in normal as well as in learning-and memory-impaired mice. A single oral administration of CS-extract had no effects on memory registration, consolidation or retrieval in normal mice. CS-Extract reduced the ethanol-induced impairment of memory registration both in ST and SD tests and the ethanol-induced impairment of memory retrieval in SD test. CS-Extract decreased the motor activity (MA) and prolonged the sleeping time induced by hexobarbital. These results suggested that CS-extract ameliorates the impairment effects of ethanol on learning and memory processes, and possesses a sedative effect.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 17 (2), 217-221, 1994

  公益社団法人 日本薬学会

キーワード

• Crocus sativus
• ethanol
• passive avoidance performance
• sedative effect

詳細情報

• CRID: 1390282679599929728
• NII論文ID: 110003640513
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.17.217
• COI: 1:STN:280:ByuB28vmvVQ%3D
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 8205119
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/17/2/17_2_217/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995075744
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可