Inhibitory Effect of Fatty Acids on 8-Hydroxydeoxyguanosine Formation in Calf Thymus DNA Treated with Bleomycin-Fe(II).
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The effect of fatty acids on 8-hydroxydeoxyguanosine (8-OH-dG) formation in calf thymus DNA treated with bleomycin (BLM)-Fe (II) in vitro was studied. The formation of 8-OH-dG was greatly reduced in the presence of stearic acid (18 : 0) or oleic acid (18 : 1), however, it increased to the control level with an increase in the number of unsaturated bonds of fatty acids (18 : 2, 18 : 3). This increase in 8-OH-dG formation may have resulted from the indirect oxidation of DNA by the peroxidized unsaturated fatty acids formed by BLM-Fe (II). The inhibitory effect of saturated fatty acids on 8-OH-dG formation was observed with those possessing more than 12 methylene chains. Stearic acid also inhibited peroxidization of unsaturated fatty acids (18 : 2, 18 : 3) treated with BLM-Fe (II), however, it had no effect on ribose degradation of DNA treated with BLM-Fe (II). These results suggest that different active oxygen species are probably involved in DNA degradation and in formation of 8-OH-dG in DNA and of peroxidized products in fatty acids.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 17 (3), 391-394, 1994
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204621619584
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- NII論文ID
- 110003640548
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK2cXkt1Kntro%3D
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- ISSN
- 13475215
- 09186158
- http://id.crossref.org/issn/09186158
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- PubMed
- 7517263
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可