Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. XIII. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) on Type II Collagen-Induced Arthritis in DBA/lJ Mice.

• 三村 務

• 伊藤 正明

• 郷木 寛子

• 鈴木 信孝

• 竹内 勝義

• 辻川 和丈

• 小濱 靖弘

抄録

The effect of carboxamidemethylated Fc fragment (CM-Fc) from human immunoglobulin G (IgG) on type II collagen (C II)-induced arthritis (CIA) in DBA/1J mice was studied. CM-Fc suppressed the development of CIA while Fc fragment did not. CM-Fc inhibited the increase in serum anti-C II IgG. CM-Fc suppressed C II-induced delayed type hypersensitivity (DTH) in DBA/1J mice. Moreover, the C II-induced proliferation of splenocytes from mice immunized with C II was suppressed by the administration of CM-Fc. Following an analysis of the lymphocyte population, a decreased percentage of B220⁺ cells and ratio of L3T4⁺/Ly-2⁺ cells was observed in lymph nodes of CM-Fc administered mice as compared with those of control group. These results suggest that CM-Fc inhibits CIA by regulating lymphocyte function.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 17 (5), 623-626, 1994

  公益社団法人 日本薬学会

キーワード

• carboxamidemethylated Fc (CM-Fc)
• type II collagen
• arthritis
• DBA/1J mouse
• delayed type hypersensitivity

詳細情報

• CRID: 1390001204621133568
• NII論文ID: 110003640604
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.17.623
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 7920420
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/17/5/17_5_623/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995191654
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可