Inhibition of Carbon Tetrachloride-Induced Hepatotoxicity by Neopterins.

• 鴨脚 毅

• 小島 周二

• 吉川 一守

• 吉村 倫彰

• 城田 昌之

• 梶原 良夫

• 北畠 克顕

• 久保田 和彦

抄録

We investigated the inhibitory effects of neopterin (NP) and its reduced form, 5, 6, 7, 8-tetrahydroneopterin (NPH4), on carbon tetrachloride (CCl₄)-induced hepatotoxicity. In in vivo experiments, intraperitoneal administration of NP or NPH4 significantly inhibited the elevation of plasma alanine aminotransferase activity induced by CCl₄ in mice. In in vitro experiments using cultured rat hepatocytes, CCl₄ induced in a manner which was both time- and dose-dependent lactate dehydrogenase release, and the addition of NP or NPH4 to the culture-medium significantly inhibited its release from cells. NPH4, but not NP, reacted directly with a stable radical, 1, 1-diphenyl-2-picrylhydrazyl. These results suggest that NP and NPH4 inhibit CCl₄-induced hepatotoxicity through different mechanisms.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 17 (7), 914-916, 1994

  公益社団法人 日本薬学会

キーワード

• neopterin
• carbon tetrachloride
• hepatotoxicity
• free radical

詳細情報

• CRID: 1390001204621792000
• NII論文ID: 110003640675
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.17.914
• COI: 1:CAS:528:DyaK2MXivV2hs7o%3D
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 8000376
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/17/7/17_7_914/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995095716
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可