Anti-diabetic Activity Present in the Fruit Body of Grifola frondosa (Maitake). I.

• 久保 恵子

• 青木 久夫

• 難波 宏彰

抄録

The fruit body of Grifola frondosa (maitake), Basidiomycetes was confirmed to contain substances with anti-diabetic activity. When 1g/d of powdered fruit body of maitake was given orally to a genetically diabetic mouse (KK-A^y), blood glucose reduction was observed, in contrast to the control group in which the blood glucose increased with ageing. Moreover, levels of insulin and triglyceride in plasma demonstrated a change similar to blood glucose with feeding of maitake. Ether-ethanol-soluble (ES) and hot water-soluble (WS) fractions were prepared from the fruit body and their hypoglycemic activity was examined. Blood glucose-lowering activity was found when ES-fraction or WS-50% ethanol float (X) fraction was administered orally, but other WS-fractions were inactive. These results suggest that the anti-diabetic activity was present not only in the ES-fraction consisting of lipid but also in the X-fraction of peptidoglycan (sugar : protein=65 : 35).

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 17 (8), 1106-1110, 1994

  公益社団法人 日本薬学会

キーワード

• Grifola frondosa (maitake)
• anti-diabetic activity
• KK-A<SUP>y</SUP> mouse
• NIDDM
• blood glucose

詳細情報

• CRID: 1390001204623368192
• NII論文ID: 110003640715
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.17.1106
• COI: 1:CAS:528:DyaK2MXivFymu7c%3D
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• PubMed: 7820117
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/17/8/17_8_1106/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995191984
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可