Inhibitory Effect of Ginseng Total Saponins on Glutamate-Induced Swelling of Cultured Astrocytes.

• /

• / 馬場 明道

• KIM HackSeang

• BABA Akemichi

抄録

The effects of ginseng total saponins (GTS) on L-glutamate-induced swelling of cultured astrocytes from rat brain were studied. Following exposure to 0.5 mM glutamate for 1 h, the intracellular water space (as measured by [³H] O-methyl-D-glucose uptake) of astrocytes increased three-fold with a morphological change : the disappearance of cellular processes. Simultaneous addition of GTS with glutamate reduced the astrocytic swelling in a dose-dependent manner. GTS at 0.5 mg/ml did not affect the viability of astrocytes for up to 18 h, which was determined by a colorimetric assay for cellular growth and survival. These data suggest that GTS prevents the cell swelling of astrocytes induced by glutamate.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 18 (12), 1776-1778, 1995

  公益社団法人 日本薬学会

キーワード

• ginseng total saponin
• glutamate
• astrocytic swelling

詳細情報

• CRID: 1390282679599419136
• NII論文ID: 110003640800
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.18.1776
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• PubMed: 8787807
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/18/12/18_12_1776/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996124097
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可