A new cognition-enhancing agent, (R)-(—)-l-(benzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride. Effects on memory impairment in rats generated by cerebral embolization and basal forebrain lesions
書誌事項
- タイトル別名
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- A New Cognition-Enhancing Agent, (R)-(-)-1-(Benzo(b)thiophen-5-yl)-2-(2-(N,N-diethylamino)ethoxy)ethanol Hydrochloride. Effects on Memory Impairment in Rats Generated by Cerebral Embolization and Basal Forebrain Lesions.
- A new cognition-enhancing agent, (R)-(–)-l-(benzo[b]thiophen-5-yl)-2-[2-(A,A-diethylamino)ethoxy]ethanol hydrochloride. Effects on memory impairment in rats generated by cerebral embolization and basal forebrain lesions
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The title compound (T-588) has been evaluated for its ameliorating effect on memory impairment generated by cerebral embolization and by a basal forebrain (BF) lesion in male Wistar rats. The memory and learning deficits induced by injection of carbon-microspheres into the internal carotid artery were significantly improved by T-588 at oral dose of 3-10 mg/kg, as determined by an active avoidance response assay, whereas the reference drugs (tacrine, idebenone and indeloxazine) proved almost inactive in the same assay procedure. As far as the embolization was concerned, a significant decrease in cerebral acetylcholine and monoamines was observed. The effect on the memory impairment caused by an electrolytic lesion of the BF was assessed by a passive avoidance task. T-588 exhibited a bell-shaped dose-response curve and was most active at 1 mg/kg (oral dose), while tacrine showed equal activity at 10 mg/kg.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 18 (12), 1779-1783, 1995
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679599421312
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- NII論文ID
- 110003640801
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK28XisFSgtQ%3D%3D
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- ISSN
- 13475215
- 09186158
- http://id.crossref.org/issn/09186158
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- PubMed
- 8787808
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可