Depudecin, a microbial metabolite containing two epoxide groups, exhibits anti-angiogenic activity in vivo.

• 及川 勉

• 小野沢 千津子

• 猪瀬 雅世

• 佐々木 美幸

抄録

Depudecin, a microbial metabolite containing two epoxide groups, was tested for its anti-angiogenic activity in an in vivo assay system involving the chorioallantoic membrane of growing chick embryo. The microbial metabolite inhibited embryonic angiogenesis in a dose-dependent manner with an ID₅₀ of 320ng (1.5 nmol) per egg. It also affected the growth of vascular endothelial cells, a key event in the process of angiogenesis in vivo. These results suggest that depudecin could be promising as an anti-angiogenic agent and that its anti-angiogenic action involves an inhibitory effect on vascular endothelial cell growth.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 18 (9), 1305-1307, 1995

  公益社団法人 日本薬学会

キーワード

• depudecin
• microbial metabolite
• anti-angiogenic activity
• chorioallantoic membrane assay

詳細情報

• CRID: 1390282679597909376
• NII論文ID: 110003641047
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.18.1305
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 8845831
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/18/9/18_9_1305/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996087800
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可