Evaluation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4.

• HASHIMOTO Yuichi

• KAGECHIKA Hiroyuki

• KAWACHI Emiko

• FUKASAWA Hiroshi

• SAITO Go

• SHUDO Koichi

Abstract

Retinoids, including all-trans-retinoic acid (ATRA), its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4. Binding activity of typical retinoids to nuclear retinoic acid receptors (RARs) was also investigated. A good linear correlation between the ED₅₀ values of differentiation-inducing activity towards HL-60 cells and those towards NB4 cells was found. Binding activities of retinoids to RARα and RARβ also correlated well to the differentiation-inducing activities.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 19 (10), 1322-1328, 1996

  The Pharmaceutical Society of Japan

Keywords

• retinoid
• differentiation
• induction
• HL-60 cell NB4 cell
• retinoic acid receptor

Details

• CRID: 1390282679598847616
• NII Article ID: 110003641096
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.19.1322
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 8913505
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/19/10/19_10_1322/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997120682
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed