Clinical Application of Basic Arginine Amidase in Human Male Urine.

• MATSUDA Yoshifumi

• MIYASHITA Atushi

• FUJIMOTO Yukio

• UMEDA Takashi

• AKIHAMA Sumiyuki

Abstract

Basic human urinary arginine amidase (or esterase, called BHUAE) which is only found in male urine, was measured from normal volunteers between the age of 4 and 70 years using D-valyl-L-leucyl-L-arginine-p-nitroanilide as a substrate. BHUAE increases during early adolescence, between 8 to 17 years of age. Then, BHUAE decreases in the twenties and takes a certain range of value in the mature age group, between the late thirties and fifties.In patients with prostate cancer, a significant increase in BHUAE was demonstrated in comparison with the healthy male group (control) over 55 years old. On the other hand, patients with benign prostatic hypertrophy showed no significant elevation of this enzyme activity. It would appear that the measurement of BHUAE in urine can be used as a marker of prostate cancer in an advanced age group.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 19 (8), 1083-1085, 1996

  The Pharmaceutical Society of Japan

Keywords

• human male urine
• basic human urinary arginine amidase (BHUAE)
• prostate cancer
• benign prostatic hypertrophy
• prostate specific antigen (PSA)

Details

• CRID: 1390001204621338624
• NII Article ID: 110003641327
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.19.1083
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 8874822
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/19/8/19_8_1083/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997020785
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed