Balance of Intake and Excretion of 20 Congeners of Polychlorinated Dibenzo-p-dioxin, Polychlorinated Dibenzofuran and Coplanar Polychlorinated Biphenyl in Healthy Japanese Men.

DOI Web Site Web Site 被引用文献4件 参考文献33件
  • Kitamura Kimiyoshi
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Nagahashi Masahito
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Sunaga Masahiro
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Watanabe Shaw
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Nagao Minako
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

この論文をさがす

抄録

Daily intake from meals, and excretion from feces and sebum of 20 congeners of polychlorinated dibenzo-p-dioxin (PCDD), polychlorinated dibenzofuran (PCDF) and coplanar polychlorinated biphenyl (Co-PCB) were analyzed in healthy Japanese men who are considered to be a standard for the Japanese. Daily intake of these congeners was 84.2 ± 12.5 pg toxic equivalent (TEQ) and daily excretion from feces and sebum were 18.3 ± 5.9 and 23.8 ± 5.6 pg TEQ, respectively, indicating 22% the daily intake of dioxins from meals is excreted from feces and 29% from sebum. 1,2,3,7,8-Pentachlorodibenzo-p-dioxin (1,2,3,7,8-PeCDD), 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF) and 3,3',4,4',5-pentachlorobiphenyl (3,3',4,4',5-PeCB) were most abundant in TEQ, in meals, feces, sebum and blood. Co-PCBs were most efficiently excreted among three congener groups in TEQ, especially from sebum. Octachlorodibenzo-p-dioxin (OCDD), 2,3,7,8-tetrachlorodibenzofuran (2,3,7,8-TCDF) and 3,3',4,4'-tetrachlorobiphenyl (3,3',4,4'-TCB) were well absorbed from intestine and excreted at more than 100% of intake, mainly from the sebum. In contrast, 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin (1,2,3,4,7,8-HxCDD) and 1,2,3,7,8,9-hexachlorodibenzofuran (1,2,3,7,8,9-HxCDF) were excreted at relatively low levels from sebum, although well absorbed from the intestine, and the excretion ratios were lowest among the 20 congeners. It was suggested that 80.5-85.2% TEQ of each congener-group might be absorbed from the intestine, after taking bile excretion into consideration.

収録刊行物

被引用文献 (4)*注記

もっと見る

参考文献 (33)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ