セレン関連化合物に関する研究(第3報)セレン酸ナトリウムの急性ならびに亜急性毒性について その1

DOI Web Site 被引用文献2件

書誌事項

タイトル別名
  • Studies on Selenium Related Compounds. III. Acute and Subacute Toxicity of Sodium Selenate. (1)

この論文をさがす

抄録

The study was carried out to obtain the fundamental data about biological action of selenium in order to establish the standard of water quality for supply water. Following the previous examination on the body turnover, time-excretion, and distribution of 75Se-labeled sodium selenate after a single oral administration to rats, acute and subacute toxicity of sodium selenate were examined in Wistar rats. Acute oral LD50 value of sodium selenate for female rats was 31.5 mg/kg body weight, and its 95% confidence limit was 30.08-37.46 mg/kg body weight. In acute toxicity tests of sodium selenate, these rats showed decreased spontaneous movement, bristle and violent respiration, and had diarrhea, and then died of respiratory embarrassment with coordinate convulsion. The subacute toxicity of sodium selenate was examined by continuous oral administration of 1 and 5 mg/kg/day for 30 days in male and female rats. Subacute symptoms included a decrease in growth rate, inhibition of food intake, and fecal excretion. The outstanding pathological lesions were enlargement of spleen and kidney, edema of pancrease, degeneration of liver cells, bleeding foci in the liver, and a subacute yellow liver atrophy, and these appeared more evidently in female rats than in males.

収録刊行物

  • 衛生化学

    衛生化学 20 (1), 29-35, 1974

    公益社団法人 日本薬学会

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ