Evaluation of the Method for Nifedipine Administration for a Rapid Onset of Clinical Effect: A Clinical Study in Normal Volunteers.
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- KUBOTA Rie
- Division of Clinical Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University
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- KOMIYAMA Takako
- Division of Clinical Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University
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- SHIMADA Hideyo
- Division of Clinical Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University
書誌事項
- タイトル別名
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- A Clinical Study in Normal Volunteers
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Nifedipine is frequently used for patients who require an immediate reduction of blood pressure elevated temporarily by various administration techniques including sublingual route without administrating intravenous infusion of vasodilator. A cross-over clinical study was conducted to investigate the optimal administration method of nifedipine for rapid management of hypertension. Four method of administering 10 mg nifedipine (the capsule was bitten and swallowed, sublingually with a hole in it or the contents administered orally or intranasally with a syringe) were evaluated with regarded efficacy, safety, and usefulness in 6 normal volunteers. Systolic and diastolic blood pressures were correlated with the nifedipine serum concentration in each method. Nifedipine pharmacokinetic parameters differed among the 4 administration methods. Nifedipine was absorbed rapidly by not only intestinal mucosa but also the nasal or oral mucosa. The pharmacological effect of intranasal or sublingual administration was superior. However, mint oil which is present in nifedipine capsules stimulates nasal mucosa when administered in tranasally. For clinical usage, nifedipine capsules in which a hole is made with a needle, administered sublingually, can be effectively and safely used for rapid management of systemic hypertension.
収録刊行物
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- 薬学雑誌
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薬学雑誌 121 (5), 355-364, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681105928960
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- NII論文ID
- 110003648524
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- NII書誌ID
- AN00284903
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- COI
- 1:CAS:528:DC%2BD3MXjt1KrtLw%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 5760609
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- PubMed
- 11360489
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可