書誌事項
- タイトル別名
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- Crystalline Molecular Complexes Generated between Surfactants and Various Additive Compounds: An Attempt to Modify Sparingly Water Soluble Drugs to Easily Water Soluble Drugs.
- カイメン カッセイザイ ト ホウコウゾクケイ カゴウブツ ト ノ アイダ ニ セイセイ スル ケッショウセイ ブンシ サクタイ ナン スイヨウセイ ヤクブツ ノ イ スイヨウセイカ エ ノ ココロミ
- An Attempt to Modify Sparingly Water Soluble Drugs to Easily Water Soluble Drugs
- 難水溶性薬物の易水溶性化への試み
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It has been established that ionic surfactants, whether cationic or anionic, provide crystalline molecular complexes stably with various aromatic compounds as additives. Among various additives phenolic compounds are especially favorable for both surfactant species. Other than these additives, cationic surfactants easily provide crystalline molecular complexes with basic materials and even with non-polar substances such as biphenyl and phenanthrene. The isolated surfactant molecular complexes were analyzed by X-ray. To date the number of the obtained surfactant molecular complexes exceeds two hundred species or more and thirty or more of them were structurally analyzed. These surfactant molecular complexes were shown to be novel surfactant species different from their mother species, supplied with enhanced solubility to the complex additives. We applied these characteristics to sparingly water soluble drugs as the complex additive to modify them into easily water soluble drugs. The obtained complex drugs revealed an improved behavior in solubility and dissolution rate compared with pure drugs.
収録刊行物
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- 薬学雑誌
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薬学雑誌 121 (6), 403-421, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681104919296
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- NII論文ID
- 110003648529
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- NII書誌ID
- AN00284903
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- COI
- 1:CAS:528:DC%2BD3MXkt1ygtrY%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 5784182
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- PubMed
- 11433775
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可