書誌事項
- タイトル別名
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- Preparation and Clinical Evaluation of Orally-Disintegrating Clonidine Hydrochloride Tablets for Preanesthetic Medication
- マスイ ゼン トウヤク ニ モチイル エンサン クロニジン コウコウ ナイ ホウカイジョウ ノ チョウセイ ト リンショウ ヒョウカ
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抄録
Orally-disintegrating tablets of clonidine hydrochloride, an α2-adrenergic agonist, were prepared by the method of drying an aqueous suspension. The suspension was prepared using powdered lactose, and the composition ratio was 2 : 1 (powdered lactose : 0.048% clonidine hydrochloride solution). The suspension was dried under 4±1°C(72±15% R.H.). We obtained tablets containing clonidine hydrochloride (40μg/tablet). Physical properties of the tablets were as follows : hardness was 4.0 kgf, and disintegration time was 41.7 s (in vitro). In the clinical use, 8 patients, aged 1-2 year and weighing 9-11 kg, received approximately 4μg/kg body weight as clonidine hydrochloride. The tablet was administered 90 min before entering the operating room. All patients were willing to accept the tablet. The quality of separation from parents, sedation and a mask acceptance were excellent on all patients. These results suggest that the orally-disintegrating tablet of clonidine hydrochloride was useful in a clinical situation for the preanesthetic medication of pediatric patients aged 1-2 year.
収録刊行物
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- 薬学雑誌
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薬学雑誌 120 (7), 652-656, 2000
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681132574208
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- NII論文ID
- 130007279911
- 110003648848
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
- http://id.crossref.org/issn/00316903
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- NDL書誌ID
- 5390627
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可