ハイドロキノン-α-グルコサイドによるメラニン生成抑制効果 Inhibitory Effects of Hydroquinone-α-glucoside on Melanin Synthesis

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Inhibitory effects of hydroquinone-α-glucoside (HQ-α-G) on the melanogenesis were investigated and compared with those of arbutin. The levels of inhibitory effects of HQ-α-G and arbutin on the tyrosinase activity were nearly the same. Inhibitory effects of both compounds on the melanogenesis, were studied using cultured B16 melanoma cells, and HQ-α-G was also found to have a similar effect to that of arbutin without inhibiting cell growth. In this experiment, while HQ-α-G hardly inhibited cell growth at 1 mM, arbutin inhibit it significantly at the same concentration. From these results it is suggested that HQ-α-G as well as arbutin inhibited the melanogenesis by affecting tyrosinase rather than by killing melanocytes. Furthermore, the melanogenesis of guineapigs with brown hair was reduced to about 80% by applying them each compound. The great differences in toxicity to normal human keratinocyte were not recognized between these two glucosides. It is, therefore, considered that HQ-α-G is an effective and safe ingredient for cosmetics.

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参考文献:  15件

被引用文献:  10件

各種コード

  • NII論文ID(NAID)
    110003648979
  • NII書誌ID(NCID)
    AN00284903
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00316903
  • NDL 記事登録ID
    3633275
  • NDL 刊行物分類
    SD0(薬学)
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z19-411
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS 
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