Inhibitory Effects of Hydroquinone-α-glucoside on Melanin Synthesis

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  • ハイドロキノン-α-グルコサイドによるメラニン生成抑制効果
  • ハイドロキノン アルファ グルコサイド ニヨル メラニン セイセイ ヨクセイ
  • Inhibitory Effects of Hydroquinone-α-glucoside on Melanin Synthesis

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Abstract

Inhibitory effects of hydroquinone-α-glucoside (HQ-α-G) on the melanogenesis were investigated and compared with those of arbutin. The levels of inhibitory effects of HQ-α-G and arbutin on the tyrosinase activity were nearly the same. Inhibitory effects of both compounds on the melanogenesis, were studied using cultured B16 melanoma cells, and HQ-α-G was also found to have a similar effect to that of arbutin without inhibiting cell growth. In this experiment, while HQ-α-G hardly inhibited cell growth at 1 mM, arbutin inhibit it significantly at the same concentration. From these results it is suggested that HQ-α-G as well as arbutin inhibited the melanogenesis by affecting tyrosinase rather than by killing melanocytes. Furthermore, the melanogenesis of guineapigs with brown hair was reduced to about 80% by applying them each compound. The great differences in toxicity to normal human keratinocyte were not recognized between these two glucosides. It is, therefore, considered that HQ-α-G is an effective and safe ingredient for cosmetics.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 115 (8), 626-632, 1995

    The Pharmaceutical Society of Japan

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