プラズマ化学の基礎と医薬品工学への応用研究

• 葛谷 昌之

書誌事項

タイトル別名

• Fundamentals of Plasma Chemistry and Its Application to Drug Engineering
• プラズマ化学の基盤と医薬品工学への応用研究
• プラズマ カガク ノ キバン ト イヤクヒン コウガク エ ノ オウヨウ ケン

抄録

In this review, our novel research works in both low temperature plasma chemistry and solid state plasma chemistry were described. As for low temperature plasma, the ESR study on plasma-induced radicals of several selected conventional polymers was shown including the detailed analyses of the radical structure and the mechanism by which the radicals were formed on typical degradable methacrylic polymers and crosslinkable polystyrene. One of the pharmaceutical applications of the plasma processing for drug delivery system (DDS) was also described, whcih includes the preparations of double-compressed tablet consisting of drugs as a core material and various types of polymers as a wall material followed by plasma-irradiation on such a tablet. As for solid state plasma, the detailed reaction mechanism of solid state mechanochemical polymerization was shown including the solid state single electron transfer and the special feature of the resulting polymers. The structural criteria for polymerizable monomer derived from the quantum chemical considerations were also established. Based on the above findings, we synthesized various polymeric prodrugs by mechanochemical polymerization and studied the nature of hydrolyses (drug release).

収録刊行物

• 薬学雑誌

  薬学雑誌 116 (4), 266-285, 1996

  公益社団法人 日本薬学会

キーワード

• low temperature plasma
• solid state plasma
• ESR
• free radical
• DDS
• drug-release

詳細情報

• CRID: 1390001206154889856
• NII論文ID: 110003649024
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi1947.116.4_266
• ISSN: 13475231
• ISSN: 00316903
• ISSN: http://id.crossref.org/issn/00316903
• NDL書誌ID: 3949202
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3949202
• Web Site: https://www.jstage.jst.go.jp/article/yakushi1947/116/4/116_4_266/_pdf
• データソース種別:
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  • NDL
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• 抄録ライセンスフラグ: 使用不可