生薬の皮膚関連酵素に対する阻害作用

• 沢辺 善之

• 山崎 勝弘

• 岩上 正藏

• 梶村 計志

• 中込 和哉

書誌事項

タイトル別名

• Inhibitory Effects of Natural Medicines on the Enzymes Related to the Skin
• ショウヤク ノ ヒフ カンレン コウソ ニ タイスル ソガイ サヨウ

抄録

In this paper, we investigated the inhibitory effects of water extracts from sixty-six natural medicines on the enzymes related to the skin, which were tyrosinase, hyaluronidase and collagenase. To clarify the inhibitory components in water extracts, tannin quantity and the inhibitory activity of the water extracts after removal of phenolic compounds using polyclar AT, were measured. Twelve kinds of natural medicines were found to have tyrosinase inhibitory activity. Six of them showed that tannin, which contains sufficient amounts in extracts, might be major inhibitory compounds due to a significant decrease of inhibition by these samples after removal of phenolic compounds. The inhibitory compound of Aurantii fructus immaturus was thought phenolic compounds except tannin. The inhibitory compounds may include Armeniacae semen, Perillae folium and Persicae semen besides a phenolic compound. Twenty-seven species among the natural medicines studied showed inhibitory activity on hyaluronidase. Phenolic compounds in these extracts except Artemisiae argyi folium, could not be candidates for hyaluronidase inhibitors. Seven kinds of the natural medicines have inhibitory activity on collagenase. It was estimated that these inhibitory compounds were phenolic compounds. These results are to be expected for finding novel compounds for skin disease or skin-care cosmetics.

収録刊行物

• 薬学雑誌

  薬学雑誌 118 (9), 423-429, 1998

  公益社団法人 日本薬学会

キーワード

• natural medicine
• enzyme inhibition
• skin
• tyrosinase
• hyaluronidase
• collagenase

詳細情報

• CRID: 1390001206154083712
• NII論文ID: 110003649172
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi1947.118.9_423
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 4551449
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4551449
• Web Site: https://www.jstage.jst.go.jp/article/yakushi1947/118/9/118_9_423/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999010415
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可