On the Evaluation of the Preparation of Chinese Medicinal Prescriptions. VI. The Changes of the Alkaloid Contents by Processing of Evodia Fruit

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  • 漢方エキス製剤の品質評価について(第6報)呉茱萸の修治によるアルカロイド成分含量変化について
  • 漢方エキス製剤の品質評価について-6-呉茱萸の修治による成分含量変化について
  • カンポウ エキス セイザイ ノ ヒンシツ ヒョウカ ニ ツイテ 6 ゴシュユ
  • On the evaluation of the preparation of Chinese medicinal prescriptions. VI. The changes of tha alkaloid contents by processing of Evodia fruit

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Abstract

A crude drug, Evodia fruit (goshuyu) was processed to detoxicate and reduce the bitter taste. Following the procedure described in Shokanron ( ?? ?? ?? ), Evodia fruit was washed in hot water, and then dried. The alkaloid contents of processed Evodia fruit was analyzed by high performance liquid chromatography. The result shows that the content of hydroxyevodiamine decreased to 0.55 times, while the content of rutaecarpine and evodiamine hardly change in the final processed material. However, evocarpine content increased to 1.3 times comparing with the untreated Evodia fruit. The phenomena was ascribed to the flowing-out of the water-soluble portion, and also the weight of extract and the intense of bitterness in the processed fruit were reduced to about 1/3 times.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 111 (1), 32-35, 1991

    The Pharmaceutical Society of Japan

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